

On February 20, 2021, DC announced a sequel comic to the show in their 2021 line-up which Patrick Schumacker confirmed on twitter would loosely tie into the third season and likely come out before the season's release. He also revealed that Dean Lorey would not be available to return as showrunner for the third season and would be replaced by Chrissy Pietrosh and Jessica Goldstein as co-showrunners alongside him and Justin Halpern.

Patrick Schumacker revealed during an interview that several new writers have been hired for the new season and that they have worked to diversifying the staff more, finding it especially important to hire more LGBT writers considering the direction they took in the last season. Patrick Schumacker and Justin Halpern estimates the third season will be released at the earliest by the end of 2021 or early 2022.

On September 18, 2020, almost three months after the second season concluded, Harley Quinn was announced to have been renewed for a third season which would be premiering on HBO Max instead of the show's previous network, DC Universe which would be closing down its video streaming. Christopher Meloni as Commissioner Gordon.
